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Thin flat cells that resemble fish scales under the microscope.
Pthrp lung cancer usmle. Lung cancers consists of small cell carcinoma sqamous cell carcinoma adenocarcinoma and large cell carcinoma. Lesions are typically central near hilar nodes with cavitating lesions seen on x ray or ct. Parathyroid hormone related protein or pthrp is a protein member of the parathyroid hormone family secreted by mesenchymal stem cellsit is occasionally secreted by cancer cells breast cancer certain types of lung cancer including squamous cell lung carcinomahowever it also has normal functions in bone tooth vascular and other tissues.
Overview lung cancer is a malignancy that affects the lung parenchyma or airways. Non small cell lung cancerepidemiology incidence second most common cancer. Small cell lung cancer is especially notorious for its numerous and distinct paraneoplastic syndromes.
It is also associated with lambert eaton myasthenic syndrome lems a paraneoplastic syndrome caused by ectopic synthesis. Small cell lung cancer. Patients are typically male with a long history of smoking.
Squamous cell carcinoma scc is a subtype of of non small cell lung cancer nsclc characterized by the appearance of squamous cells. Most lung cancers can be divided into. Some paraneoplasias are associated with many different malignancies such as tumor induced hypercalcemia which is caused by parathyroid hormone related protein pthrp produced from tumor cells.
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