A Surgical Case Of Lung Cancer With Poor General Status Associated With Parathyroid Hormone Related Protein Kamata Journal Of Thoracic Disease
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Pthrp lung cancer. Small cell lung cancer is especially notorious for its numerous and distinct paraneoplastic syndromes. Malignant hypercalcemia related to a parathyroid like factor was first postulated in 1941 by fuller albright although it was not until the late 1980s that pthrp was identified as the cause pthrp is now thought to be the most common cause of malignancy associated hypercalcemia and most knowledge of pthrp remains related to its role in. Nonmalignant conditions that have been described in association with elevated plasma pthrp levels include systemic lupus erythematosus hiv associated lymphadenopathy lymphedema of chest or pleural cavities and with benign tumors of the ovary kidney and the neuroendocrine system.
Protective effects against apoptosis support the hypothesis that pthrp may contribute to lung cancer cell survival and may promote cancer progression. Lung cancer surgery may be possible for squamous cell carcinomawith stage 1a squamous cell lung cancer surgery alone may be curative. Hypercalcemia is a common complication of cancer.
Some paraneoplasias are associated with many different malignancies such as tumor induced hypercalcemia which is caused by parathyroid hormone related protein pthrp produced from tumor cells. Parathyroid hormone related protein or pthrp is a protein member of the parathyroid hormone family secreted by mesenchymal stem cellsit is occasionally secreted by cancer cells breast cancer certain types of lung cancer including squamous cell lung carcinomahowever it also has normal functions in bone tooth vascular and other tissues. From these data our patient was diagnosed with a rare case of lung cancer which produced both ectopic pth and pthrp.
Surgery may also be considered for those with stage 1b stage ii and stage 3a lung cancer usually combined with chemotherapy and radiation therapy. Over time the cancer can spread by invading nearby lymph nodes and organs and traveling through the blood metastasizing to. Parathyroid hormone related peptide pthrp can be elevated in pregnant and lactating women and in newborn infants.
His scans revealed localized disease and the patient had surgery to remove the tumor and then was treated with chemotherapy. In addition histopathologic examination of the primary and metastatic tumors revealed the existence of pth immunohistochemically stained with anti pth antibodies suggesting an ectopic pth producing lung tumor.
Pthrp Induces Autocrine Paracrine Proliferation Of Bone Tumor Cells Through Inhibition Of Apoptosis
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Increased Serum And Urinary Levels Of A Parathyroid Hormone Related Protein Cooh Terminus In Non Small Cell Lung Cancer Patients Clinical Cancer Research
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Clinical Analysis Of 64 Patients With Lung Cancer Associated Hypercalcemia Li X Bie Z Zhang Z Li Y Hu X Liu W Zhang S Cheng G Ai B J Can Res Ther
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Recurrence Or Metastasis In Pthrp Positive Negative Expression In Download Table
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Parathyroid Hormone Related Protein Pthrp 1 34 Human Rat Mouse Eia Kit Extraction Free
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